	   SnapGene      OGCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACCCACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAAGCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGGATCCgccaccatgggaagggtcggaggcatggcacagccaatgggaagggccggggcaccaaagccaatgggaagggccgggagcgcgcggcgcgggagatttaaaggctgctggagtgaggggtcgcccgtgcaccctgtcccagccgtcctgtcctggctgctcgctctgcttcgctgcgcctccactatgctctccctccgtgtcccgctcgcgcccatcacggacccgcagcagctgcagctctcgccgctgaaggggctcagcttggtcgacaaggagaacacgccgccggccctgagcgggacccgcgtcctggccagcaagaccgcgaggaggatcttccaggagcccacggagccgaaaactaaagcagctgcccccggcgtggaggatgagccgctgctgagagaaaacccccgccgctttgtcatcttccccatcgagtaccatgatatctggcagatgtataagaaggcagaggcttccttttggaccgccgaggaggtggacctctccaaggacattcagcactgggaatccctgaaacccgaggagagatattttatatcccatgttctggctttctttgcagcaagcgatggcatagtaaatgaaaacttggtggagcgatttagccaagaagttcagattacagaagcccgctgtttctatggcttccaaattgccatggaaaacatacattctgaaatgtatagtcttcttattgacacttacataaaagatcccaaagaaagggaatttctcttcaatgccattgaaacgatgccttgtgtcaagaagaaggcagactgggccttgcgctggattggggacaaagaggctacctatggtgaacgtgttgtagcctttgctgcagtggaaggcattttcttttccggttcttttgcgtcgatattctggctcaagaaacgaggactgatgcctggcctcacattttctaatgaacttattagcagagatgagggtttacactgtgattttgcttgcctgatgttcaaacacctggtacacaaaccatcggaggagagagtaagagaaataattatcaatgctgttcggatagaacaggagttcctcactgaggccttgcctgtgaagctcattgggatgaattgcactctaatgaagcaatacattgagtttgtggcagacagacttatgctggaactgggttttagcaaggttttcagagtagagaacccatttgactttatggagaatatttcactggaaggaaagactaacttctttgagaagagagtaggcgagtatcagaggatgggagtgatgtcaagtccaacagagaattcttttaccttggatgctgacttctaaCTCGAGTCTAGAGGGCCCGTTTAAACCCGCTGATCAGCCTCGACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCTCTATGGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGT  :Ÿ      &         !   $   "                  #      /      #            (   !                                                                  #                        $   *            1      '   0   $   "      '             (      !                        %          "             "   4         #                        #                                                                                                  "   #      +                                  #   '                                                             #                     1   '         *   &                            !      !                                              	               *   1            *                                         +   $      $                      (          $      "            5   !      "      "                '      '         ñ yµùƒÁŠ	‹	Œ	‘	–	¥	¦	Ç	õ	þ	ÿ	£
¤
Íu8u÷‚µñ& yzœ¸úN�«ÆÐß±™wÂêš§	°	È	tTYmÚøUƒÚªI´�5 – ò �’ú\+�	’	 
)
±
ã
Ð{Ëv¶[É · `æ°¶Ë„°Ý—	Ò	ö	¥
ö
–Î*iv9Æ˜J®
ò‰! C “�ûO—Ñàò˜ÐÝæy¬ô•˜ÅX›¨	íù„«6$ Ž¬Çš6xó%gk9	`	±	ç	G¿ÖU¡ÍÿV5»8ÆJãj‚’" f{Ó
¼»ë–Á«	É	u,>D_{ q´æùèÁ•ÛöµÜ0 z¹b²o‹Ã*œ	5Z)ÔànÛ� �D÷|ñÖ=	z	Ž	“	Ï	*
/
ä
Ñ|òžÌŒ2Ûñ�k\ $žåês†
,Öë%{•ºÐDe¢ — Lm],72
²
ê

�kÖwÂ0uŒók·ì+Ê F ó þ“û�^ÁÁ8·â>ù# œ açîÚ‰ä	
&
Ï+j¹\l„Ñ¶‰™ÏèN�®ØÇ“©óŠ o ®õR©šŸ·N^Ý¨÷˜	¿	Ç
î6—w­S]‡1n/ t 40\ë…dÇ%ÌÓ	Û	÷	Š
¦
â*¥ð„Œ§À_«¼Ï:UÇìÇâÉ\Kÿ¯ä§ ¸ +ì±Ì§¿±6ÔÞ÷
…ÂÈüs!¨Ãw%0Bô»# D ü˜÷ÎÑbwzªÊ(Z–Ò”Û^	©	â	ÀÆëîúB‚
o‡ŠÎ[¬ Pá™­¯U™›£DY}‚°8€š¡…èÔ„7 M ”žó>�Æ?„ŒœÔu	 _!Šä?4RÊnš X yÒ­Þçõ˜Ø÷û0i°ú%ÒmÊ_Ø( ˆ �­È€[¢¥ôàþh:	²	ò:ãOVm-ÿ ¼ì	(žKk¼! 8ì£é7FsŽ#¥la	è	×œê¢|¾ÖW’9�Ëäö“ó ‹ ›yï[²²Àú•Îrþ†ƒ›è  ›ÙHÀ&Fì	HVþH6WÇÌ  ° GRÚ“/Wwì— ÂÊ	ç
?\°¯!‡çZ ½ gG±¼ö§éœ¥Ì¶Ý Ï |ãù½i¬	¸
Þ
kv�R`µ;£©Â‚Üêë €Ôjð-2E|Ê$rêúN–¡©÷lÁÓ819A Q]†Ùâ“Ý'C*i\�Üj}¼'- } É “Œ[Ä�	µ	: á™šC� Ö {rºC¬+PpÈú6©’[½o³žŸŒg y 8CRc³Èp€3	A
Ï
åéß}Õ�…¤ØiÖ– ‘dø}òñ�	”	Ð	-
0
ô
3½Ô}ŸÁÏs�	ïòÄ� Eõ×gÞž?
å
é{ôÔ#Yel] < > »ñL›Ý{	+
ÄÆÒ¹ÍÒ
3O—�‹ R þ(	>	¾
ó=p#aÇQÜÂà×, O ëâA†w	
ñ
æ"5ÕEf™X å %mŸæÊãŸ¹ì;|–»6TV! + `–½-UKŽ
õ= -Šš“×&Ñ,£�ì 	 ³ ²Ë#Vót@‡p @ Æ ß		FéÃp:HA…CuxÝœ˜ " ˜ Û 3
ŽÌ1Üô/ÕGcÌí,Ë Ÿ Mn ¤c^-8ã	IÓvË�Q±ltjžU# û dÂz·Èƒ
³
ë
(=Žl»×.MaxÅÓ.<`æz[¸ê G Ç”ü�x¡R^Â9”›* ô T‰Ü3–/�£}	”
ÈVÄàI„Â†ã’J|¬ …ÿPÖq	_–…¸?q8Ñ Nº¨L	"Û#cîzðŒú JkèØÝ¯Í	å	
$
'
R·ºÒ	kõ€ŠÍÔéÙiê‘Ú V ® ÌØ÷Š°kèùm…‹Ð�ÌjÒÈ”ô‹ � Ä bïa¸=
,ç·8‘FO¯ªS$ T ¤ ÔÖÛ4W·

"
8
R
Z
ÈÐ5?]_Có=~š»Épˆn¿* ¯ S	hkqöO_Ñ©îR™	¼	:
ëï37½hÊ7x@$®±Ç|Š2É Z p àÄÔ3¡	ùAZ	²=*TxÇô!pâaoy  „ ö›Þøg	l	À	
þFJNÀò2aECZhjoˆ:@¿   ª ¸”ôÈ
d˜ýS^5.1 J ¦ 5Yìï 1n}ù¹ë´"ÅíÄ	ò	š¦¨Á:`¬½ÈüãÈg¸ÊKGLm%bÄ e 9]ÍE
Ú…�cÐÙí¬'Þ N�' 8 u ‘ © )1o,‹*eÈ&oÜ	i
‹
À
ñwÆŽ¬%È'²J¤áP°¨]0  1 {#'ASt†ãÔ	ø	`
™
§
ã+«?‘;V5ã?œ¬½Ý]€¿Ë@ H¿Ýå—²ñŸÙ$  ²Íz¡¤é't‡
|ÃÉt³¶r—E’©Ä2²ßüCÞFv" ' ¹ rÆ…¥ÀÀÿ1ˆ		@	N
~
ø
"AQ™cx&1§´+ÿ_{OÁ  0ñ6–²å27sÕÚõ 	*	†ÌÒýŠJTµôrõˆ-' ,<J¦ÏíýÕÿY¨àüß	
T
\
þ
ht}‰“žÒõ×e�Fbe¼¥ • xM‘¯Êø‚v[Ü¤	ý	°
â
sÏÌX7Ù­	€ˆÈ  —ÏÒÜ	xŠ«)—Äj•_	›	ª	ì=Czpß4œÀ”õi E ý{6<	y	jÁ‹$7Ï( n s › í™ê]c§ËöÓˆ¾	ã	áí)5ÁÇïûƒT[ˆç$/A[­×\†Æm a®ÉTšœ¢>C�ƒ“¯Ú¿7�/¯†‰Éã>Q! Š šZr¡¤"¤¿EZ~±ë	ñ9â›ýŒ�…Ëò ¼ âQ°iV[¢¦� é›êY8 QÇ«o´	9Ÿä™Õ Q ºôð�½
ó
2èo	"îÃXÁŠÖ  * N ä l•±Ê"U?âž@…�v	ô<åŸ+5SWo ! Ú ú ŸÇ	Ë�`o-å.@F„ZbiË› 2„O§Õ!Ú"UbQ…‹7{ j`Ó®×ö
!
<
Q
Y
ÇQçøæBjŠòÓËhiéRÙ% Y jÃõ“ÓQ 2 	»	êý2EYü1<BY)n°Æ{~ó4È?`¾  d XnzmsŠøâñ	˜
™Ù9&«±Ç&fÜ¾FGM±ð & ¤¿ßèþäô	Dûd³*þ" m r �®Éé�–\‰u¦õ5i;	£	rWZÀæ#.@“ØôÅ l‡ ‰ ÆYhq £È!¡n€³	ê	6Zã. ¥˜
=œŸX ¹Éƒ¦Ùó!;änž„í*VzÕ  % c Wm¾ôÖáÿ 
—
üDPæ‰;X½E)zLè½" ½èógptÇmé	Øû C�¿:Wå"-?¤<’ó)çÔ~4 \ ¯Âíê8fY	Õ
Ö
×
‘’“¥¦£!,=>vw:;Ž��‘ÌñòäåæÓå÷cdq{|}ôõ ] 'è°Ãâ9å,G¦Z	b	ž
”§¤}6JS×xr”öþ ¡gî¤ë9�$~�çØ
Bë~X“VZÍ8ùæøeú# (ZŒßé]™Äã¨ÃæH…E±û[	•Áû´¥~-‡oMÉs•é á Wu>§\V	¸	/–7?Tîöf‡¯¹„œ³÷ÿ ^ € ë :-zªð³c	¨³·	Q­KØé4?>  Œ ç ±œŸ
£Ï»sÿy $T @oµ�Ú%­{
Èr¾ç j Ìœ:Á¬IL¢Wœìó½Wfû ¢ÏhïìI'tÏÙ
CnƒÿI*~ùÎ9Ÿ#Íù4 ! ¥ŽGèí	S\”Y7”X�[úv## 
)�êB^šä‹�©ÄÛ#4ÔV˜Ù	è
£]©	‚œ¦.¿¥)/I † [àEçFXíü\	–@P�ü"¼èpæ2ÊÑÖ ± bÅSÀIx¡Âˆ”ÓÛ–ê  ÄûH?†”0² ÃÂ	Ë	÷ ?H»±°µcˆ NM[�t  â ÿ jvhKàM½¹	0`ä@ÅY‚gˆÆ  XWd¨W	p+8U¢�÷<·…ø ¾ ÂH²¹] —÷.0´â À ?=Âœöï¨ê¦Í°º�£Þ  � Ì Ó NƒÖ�Ú.X‹¾çñd	n	­	ŠSafù!Ù5•@~à¹Î Ð Þ ì ÷ ø/<;N«
ß
´
R1lÃƒë<¶  _ ˜}ä´ú{ú>jL_¹
lw€ž©®·&¤L\ÝuìÁäî �A´€	…	c¸—ÝˆÛ¶<ªjê­? 65;’i	 
û
F¤ïôº/GQÐtz‚¤Š2 è ¶¿Z²]®�ñ3¦4™ÜœE„‘¼Ù qî!UðÂ"ÝÅ  - � 'Õ2J	YL.}‡%sûŒ(—ªø%dm·9B: ��»k
x"¢Ëëß÷wO¢~)3ÔRB µ ï "œãw¶õ`äÅ
(j*ñý³¨²�. AA‘&%+]ŸøkU�É£¿ R^‡Ú+”Û�
ï
&DÿÓsè( Â pÍÞŸ

6
®fÄŽÝ|~†½Û• ¢Â­ž	;�ûš¾áD„g  h k ~ Í”Å‹¶	J£Xš¡4HQçñtXü Ê ´%X�;?b<íâô/ÏÄà �\b€‰H
Mï›Ž £&-–­,dÏ(dûI	D“ L\J¾eC°ª·7Gh5 × H<ðqªŸú  |ª»ií^JQuÉJ
Ú
 :$ÎI  sÐDöÐC	7Oo„p€+´áÏ�%rú(Ÿ¥ z 9vÉqB
æÖ‚¯ž8åj_Ïá—¼	 ?¬ˆºB�î	]àã†ª\J´ûwO 	�Ð‚¼Ê
êŒÓ•¥Zì2þ`# D‹"Sd´!¦Hé4	Ð
T~ð•ÙY‘×$0" Ž_›åùŒªÅ˜¯Àé*™‰	�	•	¯	Æ	Ñ	ô	õ
z•hÊtÅ—IZ# B ’eñn~ó5»ò$WfÀ8	4F¾Õø^~
( ³åºÅâ CrŽðÕ….
1
é
Œ�/tÀ¹ðCdá=Ž¡*jJ+ *3­ëôQ¨/[ž¾MÆÜ$5Ú	¤ ^ªƒ§ÂÐëµMŽ
¬óº¦0 L ö¬YÑ
|]	t	á	—×êAh $‰ç3Zmƒ^× ‡ ¢èE�ØGßîýUùýNþ½Õqë'š»ç  Î FF.hvŸïÝ
æ
jœ1Q¯®É#õéM¨ËÒ7  x È Õ 7P\…Øáq’ÜZOÇ2	@
¨‘|[€²i»B‹f& ; = šfÝý,
¼ÃÅÓ<ÀÎrÑÓNPßd ² ¼òTJá
‰™!4Ô˜Œ ë ? c£ÁÞy¶		<ºLÊÛÒsBwÜ— ÆM.œ¢K	p	|	ÇÃßíHƒy•]ïp‘IÐ S £ I3¶Ì	4¶7<�ºÌÈom� ƒ pÐíóf	ø@I¼c±¿#giRwÆ á9-#  0 7 � ¨ (î"+@ên³!ÄÃ	¿
ª>b��û$JÝ$OÃ€\žØ'  ¥Åüû0‡•1rÙÿ
		)	?	M
{Ñ²ôq–Öd‰‘˜EbÝ‡EzN¤u ” š wìL‡x	ü	¯
á
Î Z#6Ö ¾BÙ®šPñ   P Ù ã ù k1áN	¼
ò
1TaçnƒYh‰  i_ýãP1º	
X
åAªÆÅFgïÇ $ b lX 
q—×UW† & çfçòäeæX	�
�9V<£(7øÒù à æ Y=D©úU	.¶¬,º3níS>e=¸ nËsÎ¡¬m‚)	}¼øž" 	aÃú>"ÓUØ	ö>º�»Ò1¤.ŽH ¿ JV¸Lo*›¡-/ Ò Ý —Õ.;³WM^„	b‰¶Ü‡eø ”t;µ¸Íãí  , ¾4Iº­�
X!¡˜Û.P‹�ÞØö'v�£ícï(!Ä ´ Á î !›Ì*ô@5
Ä
Ã)÷ðü…²¢§± 
 g ³$W>aaˆG
3àƒÎß ,FqHž¤ >uAÏ»Òï�©äë1I³Î» A ¬P§q�mï¿è¿®	‹÷ygêÄ´–Bà< á w Ç Í Ô O„×p‘ÛYŒ	N{1	Ü
iTÈZˆêL§™ºæ : ¢-™à	o	;ÞGqxÚrAvÞÏ# ‚ ¢ Ï/µémqØò			e	L
zb3��ú"6;�Iv†Dly�£ “ ™ ø 0üO0®
»
à
ÍSÄîð # a ß <ekæå
-� «µ2mÖ
R=dÑ Ñ Ü ù3·VL¬Tnµ¹)�Ýõu¢ìî' -·ÃÌ í  š=+``º4
Ã
(2ã0„H²ÍEG ¡ Oo¡¦,lÎèlMz	hyöÝwŽqu¦ßkŸå ` ™då¶û_/S¹ä­
º
Â
,mŸª´¸'	í&ÐFÂï1   N¥kµû ?k.9¸gx¯°±²³óôõ'ÛÜ®Ô]^_`RSmnop­Þ_E­®' ~~½Ê|ü@:`P	e
k
x
�
�(J¯¥ÕMaÌLT²÷®v`KV¯ « .¸f
„
‚)K‰ÜN=y¦ÊÆÿ/=5w\öî ü �‚{;aì
·Nbaû{ª®<L°* ÃËBS}ýAwµË	�	†	Þ	l
y
)d¹˜mØ°MWbe¸	køç¯@a€ëW& e¾Ø5g(É-	Q	o
t
Ž
´
>�Þ¼/«ÖÍëM ¦U³Ô¹© }•“¹¡
\ƒ*Š¥ËSu¿Ç 06÷ï3 6‘<ÒøÍ
AÝõ»z§¢{+ ÈGvy!Ñ_ÃÅ:ƒx•‹™œ* H ¬ 7ý%/Uxj	g
|
…
ü
Lð=O0>HRª¶>¥]  ˆ‘	<‘òÉWÅ5ÝÚ‡+bÁVgñ¯	=Æ  é UŠ·Ý[—³ƒž|¯¤•
QO4áX…ã‚šï"Ãt­þ± õ ý À40å~	…§š¸þ‚’½Ãä|«'K}ÛÞ¡Ô uF^:Íbí
JŠ�FOcå-A®ßrÑüß“#M!   . Ž )KÄC	r	‡	ß	ºÏÕ/­&±fr—"¹@n¸b�X (  BøÌ×	‚	Ö	ú	›
`N¹l¨°&r9! Ö3ÌQT€þ	x¶m
*9eÙXc
�ž†èJ«ùC¡ì:C§  †Cv„~z
ZM™n~ˆtüÍù)˜eAüÒ; Ò‚Iµ
q†�›p½ïÌ×à¡_ÕñxP*´þS €€ˆ¿9Ù†)©#?ß#£¬ï{ìNøVB�ç04 »hÊ.	M	R	b
u
0€“ìÎ§Ï£óûª  3 fEO6ž¼l"	E	
p
�
©
Üå$-dy7´Áû�ºÕ=C ¶ ð x·´ÏÞ°(
¢
)StlÙöT�´©H³ð4 ~–aå”ºæ	+ÓÌþç7‘Û/ #�äKléöÎ		]Õñ+‹ÀÕêò1z”Új¶ëø Ù¦
%
‰
Æ
„r‹¦¿¸»ÎkÆ
ávÈÎþRã’¨ W xÍ=v©'‹ÓÅ	™öún^ ùÑlÍÓÉ™ 7ë±lé,G”{‘VÊõ ¯ Ùø’·
~†:¨k¤À @ | BB’ùÎ
è&BÞh¼„Œ£|˜×hž•Œ, cðKÜ'	>
¸zó"`Æ–Œ+	 _,Éð
 ¸’:U ž Å bâ‚
'H-EèÒ9ÄGP°;_Ôyt�éT SˆÛ•¹“
w „“š«) U ­ Ã Õ×ÜV·Ë
#
7
¯>^ô}E‡Ñ¾
  ßgk	
9
MgÉ6ñ`?D‰ox* I ¥ 8&0R|)¸ìD
_
h
vÅ«Ø4â>I›£«·¼Êà?la¾Ü–1 /;IqÎðÔ„þ5Xy £&s
S
[
}
†
ý
gs|ˆ’�ËµÑ@P1IS�±´Þaóq¦,^À ÛÃš	½	àì(4<iËy6SÞ3›¬¿…hÇ » 
P`
ªS=’®ð8¾ážüˆÈâ€‹é
Ê  ) ° !TïÊŒP,-ÂEWÀ6a* £ilr‰Â÷’Òó	Ÿ	ð	;
P
é1XÆ8CAñ%eÛ(c¯²}hòý°3>Q l q ¸È‚V•ÅˆÕŸ 4¥¢	–
5YâåYˆƒDy›Äyÿ  [ ®Áá¼+oÆ}ŒÔ
A¤úB
5IR}ä +uUYðãbpzý   ê Vt‹Þ\˜§Â„°·	P¢³>†è#LÈõ®² i ?´Î«KR[›“òz�"q½u3 … AŠœD¿3Á	ÿG¢O¨b�›ÿ“¾åÐÚ(LÕ  þ iÁß<c_ÁãÄõX�;Å¢á Ë ö M‚÷�ÙŽ@Šù=æKm		
–%Ú[i0k}¬~ßÀ  µ&5Y\1:‘	h	ú
Kw†¥îó3¹F›Dƒp}¶2‰QÜA v_žã	
€
î
%e$þžTœÒÚ”� ¡;Š™GPæîð.úsÃ  ©%G;•]cÎõcB	H	I
NKdB¯à©¶$6' Š«‡¹�É
‹â®^ý_à/N"+ 2ó.Zð½L—Å®º4„#)e7	ˆ	Å	ó	E”]'²ÉsäL¹H«¸c¹iY$  K 6~«¡D-uÐÆîs	à	›§Ö0®øM­ýg±h&ºAŠ‚6% 
eµÜü	J	
»Âì;‚K¿˜ÉÐ\Ñî MoHc$  / 6 � § ¤'í!*2oúìÐ©a•¾ÕŒ—fDh¹ËÜn#Å8 Ø ^Ø	û	W
ÿm©­ O ñCùrÍT	œ
l�«(÷' Ô:I=!Òƒ	×	WaˆÛ†ŽdÚOº €bs:G f )ÎF
Ñîßû±¡‚  9 v «pŒî˜´p×¾0	K
Û
:x2ŽÇ�Y³‡éK;¢ ’ *2jU_K(Žât¡Q±D( }¼+jÉÍçÿ
Ry·O	d
j
w
Œ
¬
Á
+fòÚ­&Kö¥¬%^ÏDJ¬  ª -×4f'R�vÊ	,	Ý	n
s
LVd·ÉŸ¥þ4ú©õí;¨ |$TwÑ÷{
Ì
[@<u ©µ¾Ä˜)$  tE‡9ÌäPN‰Wý�ä,@­Þâ�*™ÀÐfÞ&sÚý Ó   (Buƒ÷Õ	ù	š
8ÎÔ¬q§�Ì!IB û¦" 2 ‡Ñ8DH…!	D	a
¨
ä,p…šo’6î^ÀÎúAŽæ/³òý< ³Î¥ ˆ
q¾ÔðsÍÅØàýæy“QâGµ§ { wêu¨¶
}Äç˜Fg“9ƒ—Ögÿ˜? Já&	’
·òŸ9^’T5  .:HïÓƒQf{¢¶Ê%(rëC
^
fr{‡‘œÊu´ª×3°³áH¢D`ßòk`Ð+½
w	! ( º ÿÁÚ	ï	O
ßè'0‹àBRðOd'2«,¿èü 5`P >sÇ�­ÀU¦»Á‡ *nªÓ
@ä‡’|yCŽK¼x2" Lh�@ŽØ‰[9C¾2‰�J	ù
^v•¡$¤Ù€šW€µ1|ÙP ¨‰$†:âA	G	

$#á­íù¨µ]ÙÂ&!" 5 1ò	ª¼ 3tƒÛ6	
 ë÷�”Ô‹–Ï[g¸ÐÛí‰$ ÓÑS	V
V‡k€þöÿaF 
i—³æÖ½	+	/	N	c
r
v
«
1�KU¶õýs3¤ô« 7G‚8Ëö 	Ë
ÍÓí¦¨Ã.ü  -Gî Peµÿ$§àê%	]
‘
ezÓfñ8G–]f’‘¦>' =Kg§þ�×#TZá8½mIF	
Ò
Þç&/uŠ” Ø‘¾Ø»Ø%1 4 ÒF©Ÿ	5	
U
q
ª
ÿ
Ujöf·ÂÚüE' EFÐÑŒÖýþ"#7	#	$	
�
Ñ
Ýæ%.i~Ÿcdeµ¶Z[\�½Ö×D  -ü  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                        1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 	                            	                            	                                 	                                                                                                                                                                            )                                            	                                                                                                                       
                                                6      
   
      	   	         	                                          	                                 	               5             $                  �   V               #      O                                                                                                                                                                   1                                                                                                                                                                                                                                                                                                 	          	            	           	                                                                )                	                                         
                6  
 
  	 	   	              	           	     5     $      � V     #  O   r   sÂ  sÚ  t  xP  }  ƒå}¾î
‰{©¶Êþ‚¾n³Ë
Uœ·×ðy'9ßöŒªï7À) i²C²ä•$i,¦í#³Æi??„hùA‚Ë� ,¦ÆíJbÍÔ#hkqt}¯àÈ©åÚÄ	Ü	

E
`
~
ùAtÃÉÁ,·½2V…�=‘ÔF\n |ŒÖy u	|šŒ |Œ|y|-Aæõ�‰(�Úß'2Ç •¼2$1J=¼cãÐ)†ª‘ œ-ÿÓ‚±Ü-}*/þ±žÔ÷8Ù×Ù±n)ÓûQ†Ù“'�š¡*4mÓ•hso©s·=	Ç
Ïò]Q^
3á­iÒØrç¾r §Âv] y²§J~Mý&;Q†Ù“Ï�Ü©'jÂ Û× y=ûQ×,LQ,L§ÑÝÞ ;´1l<þy]¶Ý–óQ,L¾ y„ÞÝÒ	ö	¥
9ž Ä)Ï²	PÀ	þFa
 èÜï1–­(“þŠ¾Ioì
 ß‚Q
Y
Ï™8©s·b±²ÝæÝ=	¦
²
Ç
â*Ïò5\]»ä·ðîæ‡W�™ý PÔ*î
þ@‰³âþu‡¨2½5	Þ&¡Äþs€·hïåx´²Ç}¤‡
ÄßáÔ]Îwª–ërç/Ä	ò	ÈGrÀh •@‰2¡€¬ y¶„ÞÝÒ	ö	¥
–ó=û9Q×,LäÔš@‰‡2½¡þ€�¦-ÿV ,íY]Ô#S¤ÀÔo	¼	À	N
\
‡
ëþ3Fdù;A]aŠŽÄßFcÐ&Kxÿ@‰â2¡€À	þFa*Ói,{qù• ö8® Ø…5h	ú
îFî%dB6dåä	Ðä	ÑÒ‚q†�›_ñ*yGð~Mý&îæ;ié1¯}í#² HÁÆ �¡*mÆ Ÿñ�}×^‡ë
"3š¡Q6,*L¬ ž×ß4á&y±Ý7X�S †èJšäçÔ3= Â ©Õ�@ ”¤‡
Äßl{÷ëð	8ek`
tÃ—Ñoìl÷ð	8e�¡*jÑW�‡™ý\³y å�–/\¿÷ŽzÊZ ±"Uoý[1
Œë/*×Ó,D{qù•ö0€jÊêN¡ÓA1ò¼Ú3ƒ6	ß'R2«¸…ÑP8Ô¦ ì 1hknqöùÑë:
¨7`½@$g¸Êm®±|Ä2· +ì°Ëb§²o°ÝÞö
Ô»
ù³ÎÿÓsØ’G¦DÖä
k\ŠüßMb²oÔùhkqöÑ:
7@$®±|2¦ ì 1nùë¨`½g¸ÊmÄ[9�	ù
v¤šµ1PÚ—ç
\Å
jý¶ ¦ Øì 1hknqz¡öù'Ñë
$
:
Ét¨³7`·º½©	2@²$g¸ÊÍCÞm®±|Ä2‘v1ò³Î¼Úÿ3ƒ6	ß'ÓsRØ2«¸’G¦g	Jò2ECoˆ@ G“/ÂÊ	°¯‡Z-–­(dD“\ª·h( ÿ‹O,¿5`
ë–ÁÉ	> æw}2Q ‡*ÀfK «Ðs	à	Ög‚y¸±ÂYmÚNÛ#c"œãõdûI	J¾*žñ8DG K ’ ‡«Ðs	à	Ög*Àf‚ïÂWÀ%•cÎcH	KdB¯©¶6Ý�Ü}¼¸ª-GîPeµ$ê]
ezGÝ¯'
Rkõ€‹ rC›Ô 6µ;o©Îr³þŠŒ&BhwŒ |“š), }•	C“¹<‘r	ß	µ
Õ*/­fË‡Õ6¹@þ	�	+	r
KU¶ý3ô�­È€[¥ôh:	VkmÊ3
?
I{1|»/G’Ìe!ˆ ¢²	-ÿ	žÖ3Q€m
c
žùì:§Ô ŠrC6o³Œ?
I{’e‹ ›µ;©Îrþ Øz¡'
$
Ét³·º©	2²ÍCÞ‘v%•ïcÎcH	KdB¯©¶ÂWÀ6† çFíüü¼pü ·{ª`ä�.ISU ­ Ã Õ×ÜV·Ë
#
7
¯>^ô}E‡Ñ¾
 .:HïÓƒQf{¢¶Ê%(rëC
^
fr{‡‘œÊu´ª×3°³áH¢D`ßòk`Ð+½
w	JkèØÝ¯Í	å	
$
'
R·ºÒ	kõ€ŠÍÔéÙiê‘Ú	 ³ ²Ë#Vót@‡pd XnzmsŠøâñ	˜
™Ù9&«±Ç&fÜ¾FGM±ðT ¤ ÔÖÛ4W·

"
8
R
Z
ÈÐ5?]_Có=~š»Épˆn¿Ø ^Ø	û	W
ÿm©­ O€Ôjð-2E|Ê$rêúN–¡©÷lÁÓ819A¸ +ì±Ì§¿±6ÔÞ÷
…ÂÈüs!¨Ãw%0Bô»³Î¥ ˆ
q¾ÔðsÍÅØàýæy“QâGµ§… AŠœD¿3Á	ÿG¢O¨b�›ÿ“¾åÐÚ(LÕ& d t ¸ +4ì0X\nz¤±¿Ìëms…Š§¿ßèødÇþ%±Ìä6ÔâÞô	Ó	Û	ñ	÷	Š
˜
¦
÷
…™â*¥ÂÈÙðüs„Œ§À!9_«¼Ï:DU¨ÃÇìÇâ&«±Çû&fwÉÜ%0B\¾FKd³ôÿ*G¯»äþM§±ð … ¿ þ 	aiÁÃúAJŠœ>DV¸¿ß"3<LcÓUÁ	Ø	oöÿ>G_¢ºO�¨Áb�›ã»ÿ*“›¾ÄõX¡Òå-/1�¤ÐÚ(.;LŽÅ¢ÕáHR^‡Ú+”Û�
ï
&DÿÓsè(ƒ pÐíóf	ø@I¼c±¿#giRwÆ á9-M^ € ë :-zªð³c	¨³·	Q­KØé4?>7G‚8Ëö 	Ë
ÍÓí¦¨Ã.üD ü˜÷ÎÑbwzªÊ(Z–Ò”Û^	©	â	ÀÆëîúB‚
o‡ŠÎ[¬# a ß <ekæå
-� «µ2mÖ
R=dÑE d R^‡Ú	+”ýXnzmsŠø{�ÐÛ‚â6¼<	y	ñ	�
˜
Ê
ï
&™Ùjê9DŒÓÿ•Á&¥«±Ç&ZfÜ‹¾ì$7FÏ2GÓþ`Ms±ðè#(6‘<ÒøÍ
AÝõ»z§¢{+   B     ‚  �        �7»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÏ}Žì/3üì÷Û8}4Ó�è³þÇ´¸8u]Ïý´Ó?2ø955[¯Aî<NISyOÓhADòžoóÊ²‹«öÅŸa›ƒF'QS„>ú xñ ~¯Pf´ÞNá_FªfíŠàúê0Ä‡’Öz“ÔRµ-ÑÎ*æ½Z=�g{Åbt»é¡Þ�¥F½QQnë\ö„u�¢!E8x£( uD9É�ˆ>³Œ$P[®«‚º£mf¸;Q\á�éÚ¯XNšM„�â£ãáŠÔß‚wSûÑU–Ÿ^ÂÐdM¯·D?�ˆS¶Àahß¡…4�±* ñÐéŽà*—QªÕ$U½¨zØf­äPUuzêLIIôA€IbÕ¬tU®­ú8zåìK‘ò¥8m>Çˆúä£ÓÛŠ*?ïü�¯¡þ÷¿x¾¯–U„£lÚ.B-®k€ €45 hdÐØà0€î`ë„0T_N î@	¿ÜÏâL3iLÃ ‚œÍ29Þ�LþLüï«:ºþ¾®Ïr³Ã«üµ;•°¿©¼jHêpß±ÿU^†�!‚·$€öÏá‘ÂªÏê KÜ®¥’º+Õà]wµþnÂæº¡©”¨ñ«š
UXN—Uj\Å¥® Xˆ´¤�RÿC¿ÓCE&5M�»ZKM}�RÿC¿ÓCE&5M�»ZKM}’üÿ—¼ý¿?åï?Jóö»ÏöZª¦¦4CÄ<û�¸NkÑI!:ª>Cª5TïÀN‰›Ú¬†ÔGA„*Í†…Ô`hÜÐ®ðó  D9¬9‡€Ýtu°ã¸cÏ"¼8´Í ÏÂº¨µ‹Â?……ãAÄ4Ì9²qÀÊú3N#±Ê-áLàãš� Ðnø¶íú;ãÄT›Û`á�c8ÙÎ†ðçãö±÷ÔÅvÍ±17'°`SÂè±´nM´³=<^+=Ô36?1ì²Ø1�Ž�m‚X<ê¸Û ðà"9´“(9ü†háDè0Å€áó¯²:œ&Ï;ñ¬Ó6Ï®lúèq+®î ¬VSý~=·«÷Ï>¹…B€ë²«ÀsÃ�†ûÓ0íŽ®³÷ýz*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹‰Ÿ,~ääNƒ%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy]& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË¿þ`  …     -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  <?xml version="1.0"?><Features recycledIDs="0" nextValidID="14"><Feature recentID="13" name="RRM2" directionality="1" translationMW="45038.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="908-2080" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="12" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6389-6493" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4200-4321" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3016-3151" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2124-2348" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2836-3165" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2394-2822" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4772-5357" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="G418" directionality="1" translationMW="29047.90" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3232-4026" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6319" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5528-6319" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6320-6388" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>c84247ce-c15a-47e7-ae36-0b174ccf4021</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="3:41:53">2021.4.20</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  i<StrandColors><TopStrand><ColorRange range="0..2763" colors="black"/><ColorRange range="2764..2765" colors="magenta"/><ColorRange range="2766..6556" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2763" colors="black"/><ColorRange range="2764..2765" colors="magenta"/><ColorRange range="2766..6556" colors="black"/></BottomStrand></StrandColors>   Î     €  —        —7»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìØîÂó?ÎÏ}³‡ÓM8Þ‹?áL{Kƒ‡PEÜÿ×ûM3ó/ƒ“PãPEºôãÄàT•7÷”ý6„O)áVÿ<«(º¿lYö¸4bu8Cïª�BêõkMàîôaÚ¦nØ®®£HpÙ-a �1©=E+RÝüâ®`ëÕ£Øvw¼V'K¾šéÚTkÕfîµÏhGXú"QC‡€ú2� TCœ˜q(ƒë8ÂEºê¸+ª6ÖkƒµÀð>�ªõ„é¤Ñ@¸Þ!ê>>­Mø'u?°M%QYiõì-DÐJûtCøø…;l�úSIÛ¢˜àN©u­RE[Ú‡­�jÞEWW®¡Ä�ÄŸD–-ZÇEZêß c‡®^Ä¹?*Wó†Óìx�®J==¸¢£þÿÈúúàP�{÷‹êùeXAZ6Í¢á$"Úæ¸  AÓP€QÖMŽ cæ¸CEôàä ›ýÌþ$Ã6”Ì0")ÌÓ!ó�èôÏäÏÎú³«¯ëêì÷+<:¿ËS¹[ ;ú�+Æ¤Ž§ûõUèi+rHlþ*¬þ¡Ê½ÊêY {¢½^×{_æì.kª™@j�°ù ¥U„á©uV¥ÌZZâˆ‹J@ˆ/ô;ý44RcTØÛµ¤´×Ðˆ/ô;ý44RcTØÛµ¤´×Ù/Ïù{ÏÛóþ^óô¯?k¼ÿ`áåªªjcD<CÏ¸û„æ½’Cª Cä:£UNüè™½ªÁ¸mDtA²¬Øh]F�Í
ï:CšÃ˜x×G[;†<ò+Ã‹LÐü+ª‹Qñø¼#øX^4CLÃ› à÷¯£4â;¢ÞÀP9 1Hðï‹nß£¾<EI½¶Ö0Ã�œèo~?k}LWlÛr{<.‹A†àqDÛ@;3ÓÅâ³ÐíC3cñÃnË!ýƒøèñfØ UƒÎ«�­±â Áó›AÙ2ƒŸÈfŽNƒX:û#©Âló¿Í3lúæÏ®‡ºá0à
Åañõ1Ï×ãÛq±¯|óë˜T(°[*¼<8o½3 nØàJë?×¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸™òÇîNDè2[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘EÒj	¸Îã…=)úÁU‚Nèo]_|à“
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~±Á°»ñ¿æ  …     -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ™<?xml version="1.0"?><Features nextValidID="14"><Feature recentID="13" name="RRM2" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="902-2074" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="12" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6383-6487" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4194-4315" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3010-3145" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2118-2342" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2830-3159" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2388-2816" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4766-5351" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="G418" directionality="1" translationMW="29047.90" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3226-4020" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6313" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5522-6313" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6314-6382" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="862-2092" color="#ccffcc" type="standard"/></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>c84247ce-c15a-47e7-ae36-0b174ccf4021</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="3:40:29">2021.4.20</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  i<StrandColors><TopStrand><ColorRange range="0..2757" colors="black"/><ColorRange range="2758..2759" colors="magenta"/><ColorRange range="2760..6550" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2757" colors="black"/><ColorRange range="2758..2759" colors="magenta"/><ColorRange range="2760..6550" colors="black"/></BottomStrand></StrandColors>  a      _  4         47»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÞKÒ �k�½7H0ó±.DÊ•üá´û#ë’�On(¨ÿ¿ò>¾‡ø#Þýâú¾YVV�³h¸I¶¹®  ÐtÔ A u“Cc€Â¹ƒ®ÁQ}8¹ &ÿs?‰0Í¥3‚
s4È|çz=3ù3ó¾¬êëúú»=ÊÏ¯òÔîVÀþ¤
ñ©#©Ã~ÇýUz@†
Ü’Û?†G
«?¨r�/rº–Hè¯W�uÞ×ù»šê†¦P£Æ¬>h)Ua8j]U©s–¸�b"Ò�"KýÿM˜Õ66íi-5ô"KýÿM˜Õ66íi-5öKóþ^óöüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóî>á9¯E$„ê¨ù¨ÕS¿:&oj°nQl«6Q�£sB»ÃÎ€�æ°æuÑÖÃŽá�<ŠðâÓ4?
ê¢Ô|~/þ�Ó0æÈ8=Ç+èÍ8ŽÇ(·…0ƒŽhR<A»âÛ·èï�Romƒ†5Œ0ãg:ÃŸ�ÚÇßSÛ6ÄÄÜžÁ�O¢ÆÐa¸Q6ÐÌôñx¬ô;PÌØüpÄ²È`Æ>:<Y¶`óªàklxƒÃ€ˆ0|æÐvL çò£… Ã‡Î¾Èêp›<ïÆ³LÛ>¹³ë¡Ä®¸L¸±X|}LsõøöÜF¬kß<úæ
¬Ê¯ÏïLÀ¶8ºÏßõè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.&|±û“‘:–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äQtš‚n3¸áOJ~°UD “ºÃWWß8$Âª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡,plnüoù‚   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  M<?xml version="1.0"?><Features nextValidID="13"><Feature recentID="12" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5260-5364" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3071-3192" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1887-2022" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="995-1219" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1707-2036" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1265-1693" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3643-4228" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="G418" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2103-2897" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5190" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4399-5190" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5191-5259" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="862-969" color="#ccffcc" type="standard"/></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>c84247ce-c15a-47e7-ae36-0b174ccf4021</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="3:40:11">2021.4.20</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  i<StrandColors><TopStrand><ColorRange range="0..1634" colors="black"/><ColorRange range="1635..1636" colors="magenta"/><ColorRange range="1637..5427" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..1634" colors="black"/><ColorRange range="1635..1636" colors="magenta"/><ColorRange range="1637..5427" colors="black"/></BottomStrand></StrandColors>  |ý7zXZ  æÖ´F !   t/å£àB9] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnÏoH_¯Œ´ñJB=ï\×X§ÛûS´ ës5¿¹*D®r›²{1Íëñ¯ƒÆvM•,²8<•»®su]w»á'IÆØ^ÿ(á).ëHx••Åã$IN±Òùi`XÊFä!!°üÒUH�CŒ|ÚæBï&	a›Æ¨
‹K¡Ö=ÍáP*2I 0ŠµIbA,--®zAPséñ4ˆ	1�þ¢CKS¢ôÑ—4˜?Æ‘–.èÊËbsŽ£+30rÖ…p}“‹0âUåj»ã¸�ô?÷!Ý6ùÄeàÌ¶Æ¥ykþÃ9œqE¿rŽê1rx® ÉËYýS)JIr¥œ1Ñóö=<_ OÜ« }¹Kjç?{ƒ^G—[�]6ŸmnŽ9âXÛGÛd–%�u#£º]ž žÚ®B§;Úd“"0«‚;^?ß?Ñô×.5
fu?—‹@1bŸ+ê²ènú|?“Œ.v”å˜¾GlôT„J°ü«OÙ¼¤=þë=mG§+ßaÉœö‚õ«›wìtVp6Â…èB·f¨¶÷ËrŠ*é¥�Ý�öì!÷4mæ?ÿ^�P³äƒ¿9@«	pY[(p¬_Ò(•@íTKô�öäàVFÄmkP£ÙiåNçO� ìÉ+©³m=�fÕÎóAÁ|ze&A¡o/ì&ïŠ7Ì²?ì¸�¬#Å”4S]ÏRøÂ1É�ö´&-ë;ñ[½öË)UüpÑ¯õbfLùb1š‘<hÞ	£WÊÔ°'þgÃ,½_Ü $
óá©—t“ô$|á…,é‡'à4±4^±êÐÃyÈ…EÚ.P JáK4V-ÏÑÛ½ù£©.Ÿ}P±ælËš~ƒõy½ï„Ë“þû»Ï|š·#’€ÑgPí|à±Ãê°¬€ ¹�ºØúï­}l’}4r-x*Jæ?)OÔ‰Ý	0b0áÞf4Å–uN ¿’„¥ÖÑèó$€šÚ]T|D¦œkn³�¼g“€z´vq1ú~ßqÑ|=e—-'kxææ(Í*¥ä× š[mmçÅA<µsß|úzÍÂRÉSŽêu°Èº¡V.gHy�º�§"ë÷›×$"Ò â(ÜƒÎJ¯ð—ôIpÒbÖª©*À¼¤!^Èù( ª+!RÍs‹Ó ò×jÄÊf±È¸ø¶”Ïe¢³âù%Ú'ÒÏK–”d›1m“Ò“$Î‘²Ô×¢¾ÄŽ¨…¯±hQÐpš¦Ý]eîLKŸ[÷|x=I_×s¾ÅÞ�ëÞ$›BüöÑßä@Ýïâ)À#k¼³ññ÷PÝÍPQ?94“Èß2cü9Êšžg	‰Í¹L®Ö2
�}Igµ&�§Ç~¼f•œj°3GÝ<™Mv~œ _íÇ<íÓÕ0Œ$,öŠ'û¦XJ[…ª&û(m7;H’{-¢ˆJ&g™"l(ú½ÔÑ‘Jœ|.}Ùx”Ó7Ì)b¦Þ8["“Í:«5Wô²Ž‹a�|Ë…°Âb+ÛKRS¥14”ØÔ}I°£Û¾Èôd(çŸ®) -™‰¥G'6öÛ=‹�‚^¼O«ðA¦q.�õ ÞV[Eüa�¨ÍÐ�‚ðKoþ�ÇDzìïx·õmuËCL™ZÖâUÌ·’0K‘SŠ—»œ‰8õØÎ4´%3%"P‡±	ÏŠÊiäÔL‹û:ÞíùÞåAv?:E=_¤1+m+q}s3NÚ5ä‘‰a€´0ßq×ñ/ÛÔCZq•-ËQòÖ'*\NÒ·³‚»ÊÀˆa¿6Kåþµ¡že±
|å…âÞ{d6‘zLÐî&FbÞÇ3qWåÞø�Î‹F)–ˆúƒméCßE²,J¹EYâ|) Õ7†RÞM¼d�Ìh*”x£¨#Úó‡=Kèf,°±p"6hl³«ÜJ©ãR�…O¿k×ê5›ËðLS(Ò¾`ehòÊµÈ¾gÍ]åòfV¢@à%§z%h2'«é­ÖR�žË‚� ZÓÖ?Š²
R$„³âí![jŒ;àÿZ¨‚hÈl)Pw»¥*Ô,ËÆ6šžËâ¡ÂŽigì¼1Îû®ÿŠÔðŠôÏïJ‰)"ÖÖáC0ÿ�ŸÕ æèz`Öýî6+Ô†ÃÎ>yRŽu+#PÓºP2×Ë{‡ÊßgE¿‹«º\>p°çräF=Ný6öŠC=™ß ÝA:žÈç¸~‡Jš>p� *ðQæ’DúG›õ½Ùá Å­*ˆ‚žÃOP“~2skGIÅ%ó.Ü�Žð”c(ëÛBçÛxæ©-c1�",Ø­ýSÚVj{•Í9g…'âvs30zX©y_¡n!�Éì»`6Hª€	ˆØ´¹†˜_Qš€ŠÌ7-í9P©‹PL�Ä?–ÐBãÆ¬©¬�âŸ’à.ÌDÝkmˆ!ë¶•KJÙú’¼á¼‰ÚöV�¶ K)zî{`ÂAiŸPo‚êeža¾›OÑ ‘3Q —lùë¹…ºü…Lï‚O\I�h¡ƒ!lÉœkÞ}Ê:Šª³u¸Ÿº8Þ~|½‹Kv¿•mçµT?3vMøö‹úò	ñrOš
>�½üg¢ž!ýv/~¹±)�§û¯Íie§>§Ö%TÄè!§VCÅ¿õ3l+6n–z€Ü�>ul‘óüëvæÐ ºâf©½"þ¼      MR›z”2i Õ „ ÛU
S±Ägû    YZ  [      F®ZTR

BASE      0è  xÁA  ƒ°YãxÔ þµ,9@,ÜfÆ0ÇŠÁ’I
[ ƒ2[mXCSI³æ4Ì,¬XVZÊeJÀh[™a6 ­€ÊJ™Ë–M0¡EÍ’b¬	%©Ð˜%²	›&kl`ÚÊH2©•Y˜™¦£­ZekÕ@’M˜ ‰¬¨If3VR 56e“di®²Æ”Aäpt@ÓRl2�ÍÄ•(±Å4«¥
)sÂ¦²lZ–5DØ$W	mRƒ1 ÔÊjYEÖ‚Á0B*´hUJ›Pm0%ÈÜfÙ‚l`Y›9SV%FSrÖl¦¤mD ‘™æ¶J¶Q*k6himŒ-EÓÜÜR€¦Ù´,B²)#’¶0GÛ£!07·m•™Læf’¦8�BÃ  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  \     G®ZTR

BASE      1è  xÁA  ƒ°Yãx` þµ,9ª
l‘s®8"Pq¹áÊ�°Á0œ8FE¨�+G¶pƒÜjhä,¦)Ê*¨fQ²IaTZ%
¤°
*­ÈÌ2+bP.W´¨š©-Q×TÒ¦kºr9s.7s™Nq,çÔikjÎLeb¡&I.É9Ó\På$·š!�˜¦¥.²BÍ¦+%!4£(æ¦©X¤8 É¥jÙŠb‘ær¨šæ¶&sSeFCYŒ¹’Xc”D¹é¶šFQ+tN¡�MWÁÔ¨QDŒmcLem®Üæ¶$!c%£À­Vdl#… MbC‚Ô\Û+7¶”€Ù\À£¹¹±…¸!ˆ©@@Ûœ›°”-ÀXºµ&AP®Ò-sÅV… ÔÐ±Z`kw%Ÿ  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  <AlignableSequences trimStringency="Medium"><Sequence name="58_BGH_TSS20210426-027-05057-01_A07" ID="0" sortOrder="0" trimmedRange="0..990"/><Sequence name="58_CMV-F_TSS20210426-027-05057_B03" ID="1" sortOrder="1" trimmedRange="12..996"/></AlignableSequences>  Ì‹     ÿ BC N srôe”```pðpáó³2Ô3ãö·²*Í+Î/*IMábÊqqQjZjQj^r*ƒŸ âÈ®6   ‹     ÿ BC `í•=Ž1†‡]±l¹¶ŒÊX)\B‰h°å"t‰D.\r$
BÇ1Ïî
	z„@ß+Íx~2Ž�ŒÞçåÍñ ëçÇquÿoŽ»ãûõñ‹^ßžÖÕ—wÇÁ?ÖuØtÒ ¶UæÁ–±›lî['öhM¼k¬EPÑeK†²R¯¸w'íÙÃas ²:Qk¹Öæ6wXîŒn`ÖhA HÔ¬£%1(e×D«r¯ÎÐ‚›ôÕSjê);[ &6 Ýä�{goÖSa4“ˆ]éÎ"Åënˆ·píP5£4‘“8CŒBÉZ–ìYýŒ­+Å¥ :FesÞX#VSÌ¶¬ZRŸ‰Ñ*CpTo€(¾znãìš4ÈVUE]Š¤sKuN“©$=]ÒðLM½aÊ#¤šÈBk!3©ÓÌ]	U‘[ªds‚•«r¨	ÕI¦³ÕÆ4×©µ“¡«¶ê%´¶UöÂÚJ!â±(òÓýE]ô¿ëÕn¯Áð¢®Ã›ãk�?¿}‚ÃÕc|_°É]q’ªíòñ…n„!«¬rm…„5pãZ®Ê�ê)�\ ‹Êáq�Ýƒ‹!>Ë!{–çŸ·6Ü°ƒõ²-rv53Ã©%PÁÈ)¨¾á�er·±+D½"–CÌ„q…ÏÉCÆ(b¡#u+àìmC*·í³š�PÚ‹nÃ8hœãÎ|¦‚Y™·îdRctb\`$Æì#ÊZµRY”¹ÿë€,bP¡&NkÒhþä£Þýí¿ö¢‹.úãú*¡Xe6  ‹     ÿ BC             !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ><?xml version="1.0"?><Features nextValidID="13"><Feature recentID="0" name="RRM2" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="908-2257" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MGRVGGMAQPMGRAGAPKPMGRAGSARRGRFKGCWSEGSPVHPVPAVLSWLLALLRCASTMLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF*"/></Q></Feature><Feature recentID="1" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6566-6670" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4377-4498" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3193-3328" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2301-2525" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3013-3342" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2571-2999" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4949-5534" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="G418" directionality="1" translationMW="29047.90" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3409-4203" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="12" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6496" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5705-6496" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6497-6565" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¥<Notes>
<UUID>a5932ffb-4a2c-404b-a8ae-b118e770e6d6</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pEnCMV-RRM2(human)-SV40-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="9:24:30">2025.9.3</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                             i<StrandColors><TopStrand><ColorRange range="0..2940" colors="black"/><ColorRange range="2941..2942" colors="magenta"/><ColorRange range="2943..6733" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2940" colors="black"/><ColorRange range="2941..2942" colors="magenta"/><ColorRange range="2943..6733" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
